Medications

If you have fibroids and have mild symptoms, your doctor may suggest taking medication. Over-the-counter drugs such as ibuprofen or acetaminophen can be used for mild pain. Ifmedication for fibroids you have heavy bleeding during your period, taking an iron supplement can keep you from getting anemia or correct it if you already are anemic.

A new drug, Lysteda, was recently approved by the FDA for the treatment of heavy menstrual bleeding.  LYSTEDA is a non-hormonal medication you only take during your period, as opposed to every day. LYSTEDA cannot be used as birth control and because it does not contain hormones, it doesn't have hormonal side effects. LYSTEDA is FDA-approved to help reduce Heavy Monthly Bleeding (HMB). LYSTEDA was also shown to help make a meaningful difference as early as the first menstrual cycle and for all cycles studied. Click here for more on Lysteda.


Several drugs commonly used for birth control can be prescribed to help control symptoms of fibroids. Low-dose birth control pills do not make fibroids grow and can help control heavy bleeding. The same is true of progesterone-like injections (e.g., Depo-Provera®). An IUD (intrauterine device) called Mirena® contains a small amount of progesterone-like medication, which can be used to control heavy bleeding as well as for birth control.

Other drugs used to treat fibroids are "gonadotropin releasing hormone agonists" (GnRHa). The one most commonly used is Lupron®. These drugs, given by injection, nasal spray, or implanted, can shrink your fibroids. Sometimes they are used before surgery to make fibroids easier to remove. Side effects of GnRHas can include hot flashes, depression, not being able to sleep, decreased sex drive, and joint pain. Most women tolerate GnRHas quite well. Most women do not get a period when taking GnRHas. This can be a big relief to women who have heavy bleeding. It also allows women with anemia to recover to a normal blood count. GnRHas can cause bone thinning, so their use is generally limited to six months or less. These drugs also are very expensive, and some insurance companies will cover only some or none of the cost. GnRHas offer temporary relief from the symptoms of fibroids; once you stop taking the drugs, the fibroids often grow back quickly.